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En un estudio realizado en la India, se evaluaron a 75 lactantes con diarrea. Se dividieron en 3 grupos: a) con una evolución menor de 7 días (aguda), b) con una duración de 7 a 14 días (prolongada) y c) aquellos en los que la diarrea duró mas de 14 días (intratable).
18 lactantes sanos actuaron como controles. Se estudió la relación protrombina funcional total que estaba disminuida en los 3 grupos de lactantes con diarrea.
Se presentaron manifestaciones hemorrágicas en 8 lactantes de los cuales 7 tenían diarrea prolongada o intratable.