Tanto el grosor como la hidrofobicidad de la capa de gel mucoso están disminuidos en la mucosa gástrica de los pacientes con úlcera.
En un estudio recientemente realizado, se evidencia que el Helicobacter pylori inhibe la síntesis de mucinas y disminuye la expresión de Muc5AC y Muc1.
La disminución de la síntesis de mucina gástrica in vivo puede producir la disrupción de la capa protectiva de mucinas de superficie, siendo este un mecanismo más que liga al Helicobacter pylori en la fisiopatología de la enfermedad ulcerosa gastroduodenal.
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Publicado el 27 de abril de 2001
Helicobacter pylori y gastritis
Inhibición de la mucina gástrica por Helicobacter pylori
Las mucinas gástricas son glicoproteinas ricas en carbohidratos que son el componente principal de la capa de mucus, la cual protege la superficie del estómago de daños químicos, enzimáticos, mecánicos y microbianos.
Fuente: Gastroenterol 2000; 118: 1072-1079
Tanto el grosor como la hidrofobicidad de la capa de gel mucoso están disminuidos en la mucosa gástrica de los pacientes con úlcera.
En un estudio recientemente realizado, se evidencia que el Helicobacter pylori inhibe la síntesis de mucinas y disminuye la expresión de Muc5AC y Muc1.
La disminución de la síntesis de mucina gástrica in vivo puede producir la disrupción de la capa protectiva de mucinas de superficie, siendo este un mecanismo más que liga al Helicobacter pylori en la fisiopatología de la enfermedad ulcerosa gastroduodenal.