Medical News
/ Published on August 17, 2001
Infectología y genética
Enfermedad por priones: alteraciones genéticas
Se reporta un estudio experimental en el cual se evidenciaron sitios genéticos relacionados con el Creutzfeldt Jakob en relación con el período de incubación de la enfermedad
Fuente: Lancet 2001,vol 357: 9268.
Luego de la extracción del ADN, el genoma reveló tres regiones de relación significativa en los cromosomas 2,11 y 12. Los investigadores proponen que es probable que esto suceda también en el hombre a causa de la correlación de la secuencia entre los genomas del hombre y del ratón. El descubrimiento de estos loci en humanos permitiría detectar a las personas con más riesgo de padecer esta enfermedad.
En el hombre, los casos reportados de la variante de Creutzfeldt Jakob pertenecen al genotipo MM, y podrían estar genéticamente predispuestos a tener períodos de incubación más cortos. Teniendo en cuenta estos hallazgos, los autores sugieren que el número estimado de casos potenciales de esta enfermedad podría aumentar.
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