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Ensayo clínico controlado randomizado en donde se estudiaron 260 pacientes quirúrgicos críticamente enfermos con tres días en cuidados intensivos.
Los investigadores aleatorizaron la muestra para recibir fluconazol 400 mg diarios o placebo.
Ellos observaron una reducción del 55% de las micosis después de ajustar los datos según el escore APACHE III. No se observó cambios en la mortalidad. No se desarrolló resistencia. Los autores recomiendan reservar la profilaxis para pacientes quirúrgicos que permanecen en terapia intensiva por lo menos 3 días.