Medical News
/ Published on August 2, 2001
Esquizofrenia
Efecto de la clozapina en el tamaño del núcleo caudado
Estudios previos han mostrado que el volumen del núcleo caudado aumenta en pacientes esquizofrénicos tras el tratamiento con antipsicóticos típicos pero disminuye cuando se cambia el tratamiento por olanzapina.
A partir de esto, los investigadores estudiaron si este hecho estaba de algún modo relacionado con la mejoría clínica. En base al estudio de 22 pacientes observaron que el caudado izquierdo tuvo una reducción significativa en pacientes respondedores a la droga, pero no en pacientes que respondían a la clozapina a las 52 semanas de tratamiento. Sobre todo, el grado de reducción del volumen del caudado izquierdo estuvo significativamente relacionado con el grado de mejoría en los síntomas positivos y generales, pero no en los síntomas negativos. ![IntraMed](data:image/svg+xml,<?xml version="1.0" encoding="UTF-8"?>%0A<svg id="Capa_1" xmlns="http://www.w3.org/2000/svg" version="1.1" viewBox="0 0 1080 315">%0A <defs>%0A <style>%0A .st0 {%0A fill-rule: evenodd;%0A }%0A%0A .st0, .st1 {%0A fill: %23002bc7;%0A }%0A%0A .st2 {%0A fill: %23fff;%0A }%0A </style>%0A </defs>%0A <g>%0A <circle class="st2" cx="141.5" cy="179.93" r="135.02"/>%0A <g>%0A <path class="st2" d="M350.28,126.97v106.62c0,7-4.04,11.22-10.41,11.22s-10.5-4.22-10.5-11.22v-106.62c0-7,4.13-11.22,10.5-11.22s10.41,4.22,10.41,11.22Z"/>%0A <path class="st2" 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