Medical News
/ Published on August 17, 2001
Vacunas para viajeros HIV positivos
Disminución de la inmunogenicidad de la vacuna de hepatitis A
Se realizó un estudio en pacientes HIV positivos, en el cual se observó disminución de la inmunogenicidad de la vacuna de hepatitis A, relacionado al nivel de CD4.
En el Congreso de la Sociedad Internacional de Medicina del Viajero, realizado en Innsbruck, Austria, en mayo del corriente año, Kemper C y colaboradores publicaron un trabajo acerca de la inmunogenicidad de la vacuna de hepatitis A (Havrix 1440) en viajeros HIV positivos. Se eligieron pacientes con serología negativa para hepatitis A, recibiendo HAART, estables en el momento de la admisión, sin evidencias de infecciones oportunistas o neoplasias relacionadas con el HIV, y se los estratificó según recuento de CD4. Se observó disminución de la inmunogenicidad de la vacuna de hepatitis A: en los que tenían más de 200 CD4, la respuesta luego de 2 dosis de vacuna fue 68%; sólo 9% con menos de 200 CD4 respondió a la vacunación. 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