Antecedentes:
Los regímenes con cursos cortos de antibióticos, que varían en su duración desde una única dosis hasta 3 días, son los estándares actuales de cuidado para el tratamiento de las infecciones agudas del tracto urinario inferior (UTIs) en las mujeres adultas.
A pesar de que múltiples estudios con pequeñas muestras randomizadas y controladas (RCTs) no mostraron diferencias en cuanto a la eficacia entre el cursos corto ( 3 días) y el largo (7-14 días) para la terapia de niños, la preocupación acerca de la existencia de pielonefritis oculta y cicatrices renales han motivado recomendaciones estándares de 7 a 14 días de antibióticos para las UTIs en niños.
Objetivo:
Determinar si la terapia antibiótica con cursos largos es más efectiva para el tratamiento de las UTIs en niños y explorar fuentes potenciales de heterogeneidad en los resultados de estudios existentes.
Artículo comentado por el Dr. Edgardo Checcacci; editor responsable de IntraMed en la especialidad de Pediatría
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