Un equipo de la Washington University de Saint Louis (Estados Unidos) cree que estimulando tal proceso en las células tumorales e inhibiéndolo en las sanas puede servir para que el tratamiento oncológico sea más seguro.
El hallazgo permite conocer mejor por qué los fármacos pueden desencadenar la apoptosis en las células tumorales y no en las sanas. Comentan que el proceso químico en cuestión inactiva una proteína celular llamada Ncl-xL, la cual parece provocar que las células sean más susceptibles a la apoptosis durante el tratamiento con fármacos que dañan el ADN. El proceso por el que se desactiva la citada proteína se llama deamidación.
Observaron que este proceso que tiene lugar en las células tumorales se suprime en las células sanas, tal como comprobaron en cultivos.
Webs Relacionadas
Washington University in St. Louis
http://www.wustl.edu/
Cell
http://www.cell.com/
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