Semaglutida y tirzepatida no actúan igual en todos los pacientes: podría ser la genética
Un nuevo estudio genómico ayuda a explicar por qué no todos los pacientes responden igual a los agonistas del receptor de GLP‑1. Se analizaron datos de 27 885 usuarios de estos fármacos en la base de 23andMe y se halló que una variante en GLP1R (rs10305420) se asocia con una pérdida de peso ligeramente mayor, en torno a 0,76 kg adicionales por alelo. Otra variante (rs1800437) se relacionó con mayor riesgo de náuseas y vómitos en quienes reciben tirzepatida.
📚 Fuente: Genetic predictors of GLP1 receptor agonist weight loss and side effects
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