🧬 LA TRIMETILAMINA (TMA) PODRÍA CAMBIAR LA PREVENCIÓN DE LA DIABETES TIPO 2
Un equipo internacional (Imperial College London, Universidad de Lovaina, Universidad de Ottawa) publicó en Nature Metabolism un mecanismo protector inesperado contra la diabetes tipo 2.
La trimetilamina (TMA) —subproducto del metabolismo bacteriano intestinal de colina (huevos, pescado)— inhibe IRAK4, una proteína clave que gatilla la inflamación crónica sistémica.
🎯Mecanismo:
En dietas altas en grasas → disrupción barrera intestinal → translocación bacteriana → hiperactivación IRAK4 → inflamación crónica → resistencia insulínica.
- TMA interviene: Se une a IRAK4 → ↓ señalización inflamatoria → restaura sensibilidad insulínica → previene sepsis (modelos murinos).
Esto abre una nueva vía terapéutica en nutrición para la prevención de la diabetes.
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