💊 Nueva Aprobación de la FDA: Uplizna para miastenia gravis
La FDA aprobó el 14 de diciembre el uso de uplizna (inebilizumab) para el tratamiento de la miastenia gravis generalizada (gMG) en adultos.
🔬Mecanismo:
- Uplizna es un anticuerpo monoclonal anti-CD19 que causa depleción de las células B, reduciendo la producción de autoanticuerpos patógenos.
- Originalmente aprobado para el trastorno del espectro de neuromielitis óptica (NMOSD), esta nueva indicación ofrece una opción dirigida para pacientes con gMG que no responden adecuadamente a terapias convencionales o que buscan alternativas con dosificación semestral (tras la fase de carga).
Se une a la creciente lista de biológicos (como los inhibidores del complemento y anti-FcRn) que están transformando el manejo de la miastenia, permitiendo enfoques más precisos que la inmunosupresión generalizada.
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