Noticias médicas
/ Publicado el 17 de agosto de 2001
Cáncer de tiroides
Utilización de un método inmunológico para mejorar el diagnóstico preoperatorio de las lesiones nodulares de tiroides
La integración del inmunocolorante galactina-3 a los procedimientos citomorfológicos convencionales y de diagnóstico clínico representa un abordaje diagnóstico sensible y confiable para la identificación preoperatoria de los carcinomas tiroideos. Esta prueba mejora la certeza diagnóstica de la citología convencional y brinda las bases moleculares para una nueva asignación nosológica de las neoplasias tiroideas aún no clasificadas de comportamiento maligno indeterminado.
Fuente: Lancet 2001; 357: 1644-50
Este estudio internacional multicéntrico buscó determinar la utilidad de dos colorantes inmunohistoquímicos para 2 marcadores potenciales de los tirocitos malignos: galactina-3 y CD44v6.
La sensibilidad, especificidad, valor predictivo positivo y certeza diagnóstica para este método en los análisis prospectivos fue del 88%, 98%, 91% y 97% respectivamente. La sensibilidad y especificidad de la inmunodetección con galactina-3 sola, para diferenciar entre lesiones tiroideas benignas y malignas fue de más del 99% y 98% respectivamente. Y el valor predictivo positivo y la certeza diagnóstica del 92 y 99%.
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