Medical News
/ Published on August 17, 2001
Cáncer de tiroides
Utilización de un método inmunológico para mejorar el diagnóstico preoperatorio de las lesiones nodulares de tiroides
La integración del inmunocolorante galactina-3 a los procedimientos citomorfológicos convencionales y de diagnóstico clínico representa un abordaje diagnóstico sensible y confiable para la identificación preoperatoria de los carcinomas tiroideos. Esta prueba mejora la certeza diagnóstica de la citología convencional y brinda las bases moleculares para una nueva asignación nosológica de las neoplasias tiroideas aún no clasificadas de comportamiento maligno indeterminado.
Fuente: Lancet 2001; 357: 1644-50
Este estudio internacional multicéntrico buscó determinar la utilidad de dos colorantes inmunohistoquímicos para 2 marcadores potenciales de los tirocitos malignos: galactina-3 y CD44v6.
La sensibilidad, especificidad, valor predictivo positivo y certeza diagnóstica para este método en los análisis prospectivos fue del 88%, 98%, 91% y 97% respectivamente. La sensibilidad y especificidad de la inmunodetección con galactina-3 sola, para diferenciar entre lesiones tiroideas benignas y malignas fue de más del 99% y 98% respectivamente. Y el valor predictivo positivo y la certeza diagnóstica del 92 y 99%.
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