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Según se ha presentado en la Reunión Anual del Colegio Americano de Cardiología, que se desarrolla en Chicago, un prometedor procedimiento, consistente en inyectar el gen del factor de crecimiento endotelial vascular (VEGF) en las piernas de pacientes con arteriopatía periférica, no ha demostrado ser lo efectivo que se esperaba.
Científicos de la Universidad de Michigan mostraron que este tratamiento, cuyo objetivo es estimular la formación de nuevos vasos sanguíneos, no ha mejorado la sintomatología de los pacientes en mayor medida que el placebo.
El Dr. Sanjay Rajagopala, principal investigador, señaló que cada año 250.000 hospitalizaciones se atribuyen a la arteriopatía periférica en Estados Unidos.
En el estudio presentado, llamado RAVE, participaron 105 pacientes y transfirió el gen utilizando como vector un adenovirus. Los pacientes tenían entre 40 y 80 años y presentaban un grado de discapacidad similar al de los enfermos con insuficiencia cardíaca. El estudio concluyó sin que se observara una mejoría significativa de sus síntomas.
Webs Relacionadas
University of Michigan
http://www.umich.edu/
AAN 55th Annual Meeting
http://am.aan.com/