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En tres diferentes estudios con ratas, los investigadores logaron evaluar las posibilidades del EM-652 como tratamiento posmenopáusico. Para ello, trataron varios grupos de ratas con este modulador, más estrógeno, y valoraron su impacto sobre la glándula mamaria y el útero. Uno de los estudios analizó los efectos del 17 beta estradiol y el EM-624 sólo y en combinación.
Los resultados mostraron que, cuando se administraban conjuntamente, el estrógeno era bloqueado en la glándula mamaria y el útero, mientras que el EM-652 protegía los huesos y disminuía los lípidos en sangre. Al mismo tiempo, suponía una barrera para los efectos negativos del estrógeno sobre los tejidos periféricos, incluyendo la glándula mamaria y el útero.
El EM-652, en combinación con estrógenos, puede ofrecer un nuevo enfoque de tratamiento de las mujeres posmenopáusicas", han declarado los investigadores.
Webs Relacionadas
Laval University
http://www.ulaval.ca/scom/
Endocrinology
http://endo.endojournals.org/