A aula “Sulfametoxazol + Trimetoprim: uma história de sucesso há mais de 50 anos”, apresentada pelo Dr. Fernando Crivelenti, infectologista pela FMRB – USP, abordou a trajetória clínica e farmacológica do antimicrobiano com mais de cinco décadas de história, que apresenta amplo espectro de ação e excelente relação custo-benefício. O especialista destacou seu papel como opção terapêutica de primeira ou segunda linha no tratamento de diversas infecções, conforme orientações do antibiograma, discutindo ainda seu mecanismo de ação sinérgico, que bloqueia em dois pontos distintos a síntese de ácido folínico — etapa essencial para a produção do DNA bacteriano.
Além disso, a aula apresentou as principais indicações atuais para tratamento e profilaxia, incluindo infecções urinárias, respiratórias, de pele e partes moles, osteoarticulares e gastrointestinais. Também foi enfatizada sua relevância crescente no tratamento da neurotoxoplasmose em pacientes imunossuprimidos, além de seu uso em outras infecções por agentes sensíveis, como a Paracoccidioidomicose.
Esse conteúdo exclusivo oferece uma oportunidade para aprofundar ainda mais seus conhecimentos sobre o tema, clique no vídeo abaixo e assista à aula completa na íntegra.
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