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Realizado con pacientes de nueve regiones australianas, canadienses y estadounidenses por investigadores del Memorial Sloan-Kettering Cancer Center (Estados Unidos), participaron 3.550 pacientes con melanoma, sometidos a análisis para detectar la citada mutación. La historia de melanoma en sus familiares se utilizó para determinar el riesgo de este tumor a lo largo de toda la vida asociado al defecto genético. Del total de pacientes analizados, se encontraron 65 portadores de la CDKN2A. El riesgo de desarrollar el cáncer entre los portadores fue del 14% a la edad de 50 años y del 28% a la edad de 80.
Webs Relacionadas
Memorial Sloan-Kettering Cancer Center
Journal of the National Cancer Institute
Noticias médicas
Publicado el 24 de octubre de 2005
Reisgos
Riesgo genético de melanoma menor de lo que se pensaba
Un trabajo publicado en el "Journal of the National Cancer Institute" indica que los portadores de la mutación CDKN2A presentan un riesgo de desarrollar melanoma a lo largo de su vida del 28%. El porcentaje es muy inferior al determinado por otros estudios anteriores, investigaciones de familias con múltiples casos, que lo situaban entre el 58 y el 91%.