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El estudio randomizó pacientes con ataques agudos de colitis ulcerosa a recibir 4 mg/kg/día de ciclosporina endovenosa (EV) o metilprednisolona 40 mg/día en un trial controlado a doble ciego. Luego de 8 días los pacientes que quienes habían tenido respuesta recibieron la misma mediciación de mantenimiento por vía oral en combinación con azatioprina.
El seguimiento fue realizado con endoscopía, análisis de laboratorio y clínica. Los resultados mostraron que la monoterapia con ciclosporina es una alternativa segura y efectiva con respecto a los corticoides para tratar los casos severos de colitis ulcerosa.