El procedimiento busca marcadores genéticos de cáncer agresivo en las células tumorales. Los autores analizaron muestra de tumores de 86 pacientes con adenocarcinoma pulmonar en estadios tempranos y avanzados. Basándose en su análisis, crearon una lista de 50 genes asociados a la supervivencia de los pacientes.
En función de estos genes, los investigadores desarrollaron un perfil de riesgo que clasifica la agresividad de los tumores. Aplicado dicho perfil a una muestra de cánceres de pulmón en estadio temprano, fueron capaces de distinguir entre los casos de bajo y alto riesgo.
La estrategia utilizada implica el desarrollo de un índice de riesgo de supervivencia relacionada con la expresión genética, explican. De ese modo, se podrá identificar a los pacientes que necesitan tratamientos más agresivos.
Webs Relacionadas
University of Michigan
http://www.umich.edu/
Nature Medicine
http://www.nature.com/
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