Un grupo de investigadores canadienses estudiaron el efecto de añadir montelukast (un agente antileucotrienes) a la budesonida en el control de niños asmáticos que son dependientes en forma persistente de los corticoides inhalatorios.
Se realizó un estudio doble ciego randomizado multicéntrico en 279 niños con asma persistente con una edad de 6 a 14 años.
Los resultados mostraron que el montelukast fue efectivo tanto en incrementar los índices de flujo espiratorio como en disminuir el uso de beta agonistas y las crisis subsecuentes.
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