Un estudio randomizado y controlado encontró que el tratamiento con metotrexate no es más efectivo que el placebo para mantener la mejoría auditiva lograda con prednisona, en pacientes con afectación autoinmune del oído interno.
Un grupo de 67 pacientes que mejoraron con 1 mes de prednisona 60 mg/d fueron asignados a recibir metotrexate 15-20 mg/sem o placebo.
A tal punto los resultados fueron similares que se decidió interrumpir el reclutamiento de pacientes al documentarse la ausencia de diferencia a favor de metotrexate, ya que ambos grupos mostraban una declinación comparable de la audición.
Los resultados renuevan la búsqueda de fármacos efectivos y menos tóxicos para el tratamiento de la pérdida de audición de etiología autoinmune.
Para ampliar esta información, envíenos un mail a: infouru@intramed.net
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