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Alterando ligeramente una proteína llamada antígeno carcinoembriónico (CEA), que es un marcador de distintos cánceres frecuentes, entre ellos el colorrectal, se creo una nueva vacuna. Al reconocer la proteína, las células inmunes responden atacando al tumor.
En su investigación, primero utilizaron un nuevo fármaco para aumentar la cantidad de células inmunes en 12 pacientes con cáncer de colon o pulmón en estadio avanzado. Posteriormente, expusieron las células inmunes a la proteína CEA modificada y vacunaron a los pacientes con sus propias células dos veces, con una separación de 28 días.
Siete de los 12 mostraron una respuesta inmunológica significativa a la vacunación. Cinco de ellos también mostraron mejoría clínica, frenando la extensión del tumor en tres pacientes y deteniendo la progresión tumoral en otros dos.