Medical News
/ Published on August 17, 2001
Estudio de resistencia del virus HIV
Hacia el desarrollo de nuevos antirretrovirales
Se estudio el genotipo del virus HIV en pacientes con falla terapéutica a efavirenz hallándose mutaciones cuyo estudio permitiría el desarrollo de nuevos antirretrovirales.
Fuente: J Virol;2001;75: 4999-5008.
Este equipo encontró que las mutaciones ocurrían en el gen de la transcriptasa reversa e incluían las sustituciones K103N, Y188L, o G190S/E. Los investigadores replicaron in vitro dichas mutaciones, confirmaron su rol en la disminución de la susceptibilidad al efavirenz y observaron además que las dos primeras también daban resistencia a nevirapina y delavirdina.
Estos hallazgos son fundamentales para el desarrollo de nuevas drogas antirretrovirales inhibidores no nucleósidos de la transcriptasa reversa (NNRTI) de segunda generación.
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