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Se trata de los genes de la enzima conversora de la angiotensina 1 y 2. Se ha visto en ratones que cuando ambos genes se encuentran en equilibrio, los animales tienen corazones sanos.
Utilizando roedores manipulados genéticamente observaron que aquellos que son portadores del gen de la ECA 1, pero no de la ECA 2, desarrollan enfermedad cardíaca y presentan disfunción cardíaca. Se sabía que la ECA 1 genera ciertas hormonas que provocan vasoconstricción y ayuda a mantener una presión arterial correcta. Pero en este estudio se ha observado que los subproductos de esta enzima, además, pueden contribuir al desarrollo de cardiopatía isquémica y de insuficiencia cardíaca.
Según los autores, se trata de la primera investigación que muestra que la ECA 1 contribuye de forma importante a la incapacidad del corazón para funcionar correctamente. Asimismo, también ha permitido comprobar que el gen de la EC 2 desempeña un papel protector de la función cardíaca contrarrestando los efectos negativos de los productos hormonas peptídicas- derivados de la ECA 1.
Webs Relacionadas
University of Toronto
http://www.utoronto.ca/
Nature
http://www.nature.com/