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El diario norteamericano "The Wall Street Journal" ha concedido en su último número de 2005 un especial reconocimiento a Manel Esteller, director del Laboratorio de Epigenética del Cáncer del Centro Nacional de Investigaciones Oncológicas (CNIO), comparando sus descubrimientos en el este terreno con la exploración del planeta Marte por la sonda Mars Rovers o la misión Deep Impact al cometa Temple 1.
En concreto, el diario ha realizado un especial reconocimiento a un trabajo de Esteller sobre regulación de la expresión genética en gemelos idénticos, en el que se demuestra que, a medida que los gemelos envejecen o se exponen a estilos de vida distintos, sus genomas adquieren marcas de "encendido" o "apagado" genético diferentes, como la metilación del ADN y la modificación de las histonas.
Este proceso, según informa el CNIO en un comunicado, explica sus diferencias antropomórficas y su distinta susceptibilidad a enfermedades. Este trabajo de investigación del grupo de Epigenética del CNIO fue publicado en julio de 2005 en "Proceedings of The National Academy of Sciences".
Proceedings of the National Academy of Sciences 2005;102:10604-10609