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El certolizumab pegol constituye un tratamiento efectivo para pacientes adultos con enfermedad de Crohn, según dos nuevos estudios publicados por investigadores de la Mayo Clinic (Estados Unidos) en la última edición de "The New England Journal of Medicine".
El fármaco bloquea el factor de necrosis tumoral, proteína que representa una importante causa de inflamación en la enfermedad de Crohn, que afecta a alrededor de 500.000 estadounidenses.
El primer estudio incluyó a 662 pacientes y comprobó que el 35% de los enfermos consiguió mejorar sus síntomas clínicos tras 6 semanas de tratamiento con certolizumab pegol, frente a sólo el 27% de los que recibieron placebo. Al cabo de 6 meses, las proporciones eran de 37% en el grupo de tratamiento activo y del 27% en el grupo placebo.
El segundo estudio se diseñó para comprobar su efectividad como tratamiento de mantenimiento. Se incluyó a 668 pacientes, de los cuales el 64% respondió a la terapia consiguiendo una mejoría sintomática significativa.