En los últimos 20 años de la vida de un cardiólogo se produjo una revolución en la biología molecular.
Los avances en la fisicoquímica del endotelio y del músculo cardíaco han permitido la aplicación de nuevas drogas como los inhibidores de la enzima convertidora, beta bloqueantes, estatinas, bloqueantes de los receptores de angiotensina, etc.
Todas las proteínas, tales como receptores de membrana, mensajeros, canales de membrana y enzimas relacionados con la fisiología cardiovascular, son expresados por genes.
Descubrir su alteración y ubicación en el cromosoma como fue llevado a cabo por el Proyecto Genoma Humano (HGP) permite conocer mejor estas patologías, desarrollar técnicas de ingeniería genética y una nueva disciplina que es la farmacogenómica (1).
* El Dr. Ricardo Ferreira es Editor Responsable de IntraMed en la especialidad de Cardiología
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