Una guía práctica | 09 JUN 20

Mycoplasma genitalium: diagnóstico y tratamiento

Es una superbacteria cuya transmisión por vía sexual y la facilidad con la que desarrolla resistencia genera gran preocupación sanitaria
Autor/a: Nicolas Pinto-Sander, Suneeta Soni BMJ 2019;367:l5820 (Published 18 October 2019).
INDICE:  1. Texto principal | 2. Referencias bibliográficas
Referencias bibliográficas

1 Robert M. Emerging sex disease MG ‘could become the next superbug’. BBC News 2018 Jul 11. https://www.bbc.co.uk/news/health-44777938

2 Taylor-Robinson D, Jensen JS. Mycoplasma genitalium: from Chrysalis to multicolored butterfly. Clin Microbiol Rev 2011;24:498-514. 10.1128/CMR.00006-11 21734246

3 McGowin CL, Totten PA. The unique microbiology and molecular pathogenesis of Mycoplasma genitalium. J Infect Dis 2017;216(suppl_2):S382-8. 10.1093/infdis/jix172 28838077

4 Simms I, Eastick K, Mallinson H, etal . Associations between Mycoplasma genitalium, Chlamydia trachomatis, and pelvic inflammatory disease. Sex Transm Infect 2003;79:154-6. 10.1136/sti.79.2.154 12690141

5 Dean G, Whetham J, Soni S, Pitt R, Alexander S. Pelvic inflammatory disease (PID), Mycoplasma genitalium and macrolide resistance in England. Sex Transm Infect 2016;92(suppl_1):A12.1 10.1136/sextrans-2016-052718.30.

6 Baczynska A, Funch P, Fedder J, Knudsen HJ, Birkelund S, Christiansen G. Morphology of human Fallopian tubes after infection with Mycoplasma genitalium and Mycoplasma hominis--in vitro organ culture study. Hum Reprod 2007;22:968-79. 10.1093/humrep/del455 17158214

7 Andersen B, Sokolowski I, Østergaard L, Kjølseth Møller J, Olesen F, Jensen JS. Mycoplasma genitalium: prevalence and behavioural risk factors in the general population. Sex Transm Infect 2007;83:237-41. 10.1136/sti.2006.022970 17090566

8 Sonnenberg P, Ison CA, Clifton S, etal . Epidemiology of Mycoplasma genitalium in British men and women aged 16–44 years: evidence from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). Int J Epidemiol 2015;44:1982-94. 10.1093/ije/dyv194 26534946

9 Baumann L, Cina M, Egli-Gany D, etal . Prevalence of Mycoplasma genitalium in different population groups: systematic review andmeta-analysis. Sex Transm Infect 2018;94:255-62. 10.1136/sextrans-2017-053384 29440466

10 Getman D, Jiang A, O’Donnell M, Cohen S. Mycoplasma genitalium prevalence, coinfection, and macrolide antibiotic resistance frequency in a multicenter clinical study cohort in the United States. J Clin Microbiol 2016;54:2278-83. 10.1128/JCM.01053-16 27307460

11 Falk L, Fredlund H, Jensen JS. Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection. Sex Transm Infect 2005;81:73-8. 10.1136/sti.2004.010439 15681728

12 Thurman AR, Musatovova O, Perdue S, Shain RN, Baseman JG, Baseman JB. Mycoplasma genitalium symptoms, concordance and treatment in high-risk sexual dyads. Int J STD AIDS 2010;21:177-83. 10.1258/ijsa.2009.008485 20215621

13 Hjorth SV, Björnelius E, Lidbrink P, etal . Sequence-based typing of Mycoplasma genitalium reveals sexual transmission. J Clin Microbiol 2006;44:2078-83. 10.1128/JCM.00003-06 16757601

14 Horner PJ, Martin DH. Mycoplasma genitalium Infection in Men. J Infect Dis 2017;216(suppl_2):S396-405. 10.1093/infdis/jix145 28838074

15 Golden MR, Workowski KA, Bolan G. Developing a public health response to Mycoplasma genitalium. J Infect Dis 2017;216(suppl_2):S420-6. 10.1093/infdis/jix200 28838079

16 Soni S, Horner P, Rayment M, etal . British Association for Sexual Health and HIV national guideline for the management of infection with Mycoplasma genitalium (2018). Int J STD AIDS 2019;30:938-50. 10.1177/0956462419825948. 31280688

17 Jensen JS, Björnelius E, Dohn B, Lidbrink P. Comparison of first void urine and urogenital swab specimens for detection of Mycoplasma genitalium and Chlamydia trachomatis by polymerase chain reaction in patients attending a sexually transmitted disease clinic. Sex Transm Dis 2004;31:499-507. 10.1097/01.olq.0000135992.98883.e4 15273584

18 Bjartling C, Osser S, Persson K. Mycoplasma genitalium in cervicitis and pelvic inflammatory disease among women at a gynecologic outpatient service. Am J Obstet Gynecol 2012;206:476.e1-8. 10.1016/j.ajog.2012.02.036 22483084

19 Lis R, Rowhani-Rahbar A, Manhart LE. Mycoplasma genitalium infection and female reproductive tract disease: a meta-analysis. Clin Infect Dis 2015;61:418-26. 10.1093/cid/civ312 25900174

20 Soni S, Alexander S, Verlander N, etal . The prevalence of urethral and rectal Mycoplasma genitalium and its associations in men who have sex with men attending a genitourinary medicine clinic. Sex Transm Infect 2010;86:21-4. 10.1136/sti.2009.038190 19843536

21 Cohen CR, Mugo NR, Astete SG, etal . Detection of Mycoplasma genitalium in women with laparoscopically diagnosed acute salpingitis. Sex Transm Infect 2005;81:463-6. 10.1136/sti.2005.015701 16326847

22 Cohen CR, Manhart LE, Bukusi EA, etal . Association between Mycoplasma genitalium and acute endometritis. Lancet 2002;359:765-6. 10.1016/S0140-6736(02)07848-0 11888591

23 Jensen JS, Cusini M, Gomberg M, Moi H. 2016 European guideline on Mycoplasma genitalium infection. International Union Against Sexually Transmitted Infections. 2016. https://www.iusti.org/regions/Europe/pdf/2016/IUSTI_mycoplasma_guidelines2016.pdf

24 ASHA (Australasian Sexual Health Alliance). Australian STI management guideline on Mycoplasma genitalium. 2018. http://www.sti.guidelines.org.au/sexually-transmissibleinfections/mycoplasma-genitalium

25 Unemo M, Bradshaw CS, Hocking JS, etal . Sexually transmitted infections: challenges ahead. Lancet Infect Dis 2017;17:e235-79. 10.1016/S1473-3099(17)30310-9 28701272

26 Read TRH, Fairley CK, Murray GL, etal . Outcomes of resistance-guided sequential treatment of Mycoplasma genitalium infections: a prospective evaluation. Clin Infect Dis 2019;68:554-60. 10.1093/cid/ciy477 29873691

27 Lau A, Bradshaw CS, Lewis D, etal . The efficacy of azithromycin for the treatement of genital Mycoplasma genitalium: a systematic review and meta-analysis. Clin Infect Dis 2015;61:1389-99. 10.1093/cid/civ644 26240201

28 Abstract book. Conway R, Cook S, Malone C, Bone S, Hassan-Ibrahim M, Soni S. Clinical evaluation of the SpeeDx Resistance Plus MG assay at a UK sexual health clinic. Int J STD AIDS 2019;30(suppl_7):4.

29 Abstract book. Goh S-M, Henderson-Cleland C, Jagjit-Singh G, et al. Very high prevalence of macrolide resistance mutations in Mycoplasma genitalium in men presenting with non-gonococcal urethritis in London. Int J STD AIDS 2019;30(suppl_7):3.

30 Read TRH, Murray GL, Danielewski JA, etal . Symptoms, sites and significance of Mycoplasma genitalium in men who have sex with men. Emerg Infect Dis 2019;25:719-27. 10.3201/eid2504.181258 30882306

31 Murray GL, Bradshaw CS, Bissessor M, etal . Increasing macrolide and fluoroquinolone resistance in Mycoplasma genitalium. Emerg Infect Dis 2017;23:809-12. 10.3201/eid2305.161745 28418319

32 Deguchi T, Ito S, Yasuda M, etal . Surveillance of the prevalence of macrolide and/or fluoroquinolone resistance-associated mutations in Mycoplasma genitalium in Japan. J Infect Chemother 2018;24:861-7. 10.1016/j.jiac.2018.08.009 30190106

33 Anagrius C, Loré B, Jensen JS. Treatment of Mycoplasma genitalium. Observations from a Swedish STD clinic. PLoS One 2013;8:e61481. 10.1371/journal.pone.0061481 23593483

34 Manhart LE, Jensen JS, Bradshaw CS, Golden MR, Martin DH. Efficacy of antimicrobial therapy for Mycoplasma genitalium infections. Clin Infect Dis 2015;61(Suppl 8):S802-17. 10.1093/cid/civ785 26602619

35 Hamasuna R, Le PT, Kutsuna S, etal . Mutations in ParC and GyrA of moxifloxacin-resistant and susceptible Mycoplasma genitalium strains. PLoS One 2018;13:e0198355. 10.1371/journal.pone.0198355 29883482

36 European Medicines Agency. Disabling and potentially permanent side effects lead to suspension or restrictions of quinolone and fluoroquinolone antibiotics. 2018. https://www. ema.europa.eu/en/medicines/human/referrals/quinolone-fluoroquinolone-containingmedicinal-products.

37 Read TRH, Jensen JS, Fairley CK, etal . Use of pristinamycin for macrolide-resistant Mycoplasma genitalium infection. Emerg Infect Dis 2018;24:328-35. 10.3201/eid2402.170902 29350154

38 Sethi S, Zaman K, Jain N. Mycoplasma genitalium infections: current treatment options and resistance issues. Infect Drug Resist 2017;10:283-92. 10.2147/IDR.S105469 28979150




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