Cómo evaluarla y tratarla | 09 JUN 19

Deficiencia de vitamina B12

Se discuten las indicaciones clave de las pruebas de B12 y los análisis de primera y segunda línea recomendados, junto con algunos de los problemas que rodean su interpretación
Autor: Nithya Sukuma BMJ 2019;365:l1865
INDICE:  1. Página 1 | 2. Referencias bibliográficas
Referencias bibliográficas

1 Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ 2014;349:g5226.10.1136/bmj.g5226. 25189324

2 Stouten K, Riedl JA, Droogendijk J, etal . Prevalence of potential underlying aetiology of macrocytic anaemia in Dutch general practice. BMC Fam Pract 2016;17:113.10.1186/s12875-016-0514-z. 27542607

3 Sukumar N, Adaikalakoteswari A, Venkataraman H, Maheswaran H, Saravanan P. Vitamin B12 status in women of childbearing age in the UK and its relationship with national nutrient intake guidelines: results from two national diet and nutrition surveys. BMJ Open 2016;6:e011247. 10.1136/bmjopen-2016-011247. 27519920

4 Rogne T, Tielemans MJ, Chong MF, etal . Associations of maternal vitamin B12 concentration in pregnancy with the risks of preterm birth and low birth weight: a systematic review and meta-analysis of individual participant data. Am J Epidemiol 2017;185:212-23.10.1093/aje/kww212. 28108470

5 Sukumar N, Rafnsson SB, Kandala NB, Bhopal R, Yajnik CS, Saravanan P. Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and meta-analysis. Am J Clin Nutr 2016;103:1232-51.10.3945/ajcn.115.123083. 27076577

6 Chandyo RK, Ulak M, Kvestad I, etal . The effects of vitamin B12 supplementation in pregnancy and postpartum on growth and neurodevelopment in early childhood: study protocol for a randomized placebo controlled trial. BMJ Open 2017;7:e016434.10.1136/bmjopen-2017-016434. 28851784

7 Kumaran K, Yajnik P, Lubree H, etal . The Pune Rural Intervention in Young Adolescents (PRIYA) study: design and methods of a randomised controlled trial. BMC Nutrition 2017;3.10.1186/s40795-017-0143-5.

8 Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull 2008;29(Suppl):S126-31.10.1177/15648265080292S117 18709887

9 Ray JG, Vermeulen MJ, Langman LJ, Boss SC, Cole DE. Persistence of vitamin B12 insufficiency among elderly women after folic acid food fortification. Clin Biochem 2003;36:387-91. 10.1016/S0009-9120(03)00061-4 12849871

10 Herrmann W, Obeid R, Schorr H, Geisel J. Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk. Clin Chem Lab Med 2003;41:1478-88. 10.1515/CCLM.2003.227. 14656029 11 Devalia V, Hamilton MS, Molloy AMBritish Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol 2014;166:496-513. 10.1111/bjh.12959. 24942828

12 National Institute for Health and Care Excellence. Active B12 assay for diagnosing vitamin B12 deficiency (Medtech innovation briefing MIB40). 2015. www.nice.org.uk/advice/mib40.

13 Chan CQ, Low LL, Lee KH. Oral vitamin B12 replacement for the treatment of pernicious anemia. Front Med (Lausanne) 2016;3:38.10.3389/fmed.2016.00038. 27602354

14 Vashi P, Edwin P, Popiel B, Lammersfeld C, Gupta D. Methylmalonic acid and homocysteine as indicators of vitamin B-12 deficiency in cancer. PLoS One 2016;11:e0147843. 10.1371/journal.pone.0147843. 26807790

15 Smith AD, Warren MJ, Refsum H. Vitamin B12. In: Eskin NAM, ed. Advances in Food and Nutrition Research. Academic Press, 2018: 215-79.

16 Joint Formulary Committee. Hydroxycobalamin. BNF. BMJ Group and Pharmaceutical Press, 2018 https://bnf.nice.org.uk/drug/hydroxocobalamin.html.

17 National Institute for Health and Care Excellence. Anaemia—B12 and folate deficiency. Clinical Knowledge Summaries. 2019. https://cks.nice.org.uk/anaemia-b12-and-folatedeficiency.

18 Wang H, Li L, Qin LL, Song Y, Vidal-Alaball J, Liu TH. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev 2018;3:CD004655. 0.1002/14651858.CD004655.pub3. 29543316

19 Joint Formulary Committee. Cyanocobalamin. BNF. BMJ Group and Pharmaceutical Press, 2018. https://bnf.nice.org.uk/drug/cyanocobalamin.html.



Usted debe ingresar al sitio con su cuenta de usuario IntraMed para ver los comentarios de sus colegas o para expresar su opinión. Si ya tiene una cuenta IntraMed o desea registrase, ingrese aquí

Contenidos relacionados
Los editores le recomiendan continuar con las siguientes lecturas: