Es necesario redefinir el concepto de inflamación | 11 SEP 17

¿Qué queremos decir cuando decimos "inflamación"?

La inflamación está presente en numerosos trastornos en los que no hay daño tisular ni infección. Este artículo es una propuesta para redefinir el concepto clásico de inflamación
Autor/a: Antonelli M , Kushner I  FASEB J. 2017 May;31(5):1787-1791
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1. Weissmann, G. (2010) It’s complicated: inflammation from Metchnikoff to Meryl Streep. FASEB J. 24, 4129–4132

2. Murdoch, J. R., and Lloyd, C. M. (2010) Chronic inflammation and asthma. Mutat. Res. 690, 24–39

3. Chambers, J. C., Eda, S., Bassett, P., Karim, Y., Thompson, S. G., Gallimore, J. R., Pepys, M. B., and Kooner, J. S. (2001) C-reactive protein, insulin resistance, central obesity, and coronary heart disease risk in Indian Asians from the United Kingdom compared with European whites. Circulation 104, 145–150

4. Donath, M. Y., and Shoelson, S. E. (2011) Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 11, 98–107

5. Kushner, I. (1998) Semantics, inflammation, cytokines and common sense. Cytokine Growth Factor Rev. 9, 191–196

6. Kumar, V., Abbas, A. K., and Aster, J. C. (2015) Robbins and Cotran Pathologic Basis of Disease. Elsevier/Saunders, Philadelphia, PA

7. Orozco, L. D., Bennett, B. J., Farber, C. R., Ghazalpour, A., Pan, C.,Che, N., Wen, P., Qi, H. X., Mutukulu, A., Siemers, N., Neuhaus, I.,Yordanova, R., Gargalovic, P., Pellegrini, M., Kirchgessner, T., and Lusis, A. J. (2012) Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell 151, 658–670

8. Turk, J. L. (1994) Inflammation: John Hunter’s “A treatise on the blood, inflammation and gun-shot wounds.” Int. J. Exp. Pathol. 75, 385–395

9. Heidland, A., Klassen, A., Rutkowski, P., and Bahner, U. (2006) The contribution of Rudolf Virchow to the concept of inflammation: what is still of importance? J. Nephrol. 19(Suppl 10), S102–S109

10. Gabay, C., and Kushner, I. (1999) Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 340, 448–454

11. Kushner, I., and Antonelli,M. J. (2015) What should we regard as an “elevated” C-reactive protein level? Ann. Intern. Med. 163, 326

12. Kushner, I., Rzewnicki, D., and Samols, D. (2006) What does minor elevation of C-reactive protein signify?Am. J.Med. 119, 166. e117-128

13. Kushner, I., Samols, D., and Magrey, M. (2010) A unifying biologic explanation for “high-sensitivity” C-reactive protein and “low-grade” inflammation. Arthritis Care Res. (Hoboken) 62, 442–446

14. Nandeesha, H., Bobby, Z., Selvaraj, N., and Rajappa, M. (2015) Prehypertension: is it an inflammatory state? Clin. Chim. Acta 451(Pt B), 338–342

15. Wu,W.T., Tsai, S. S., Shih, T. S., Lin,M.H., Chou, T. C., Ting,H.,Wu, T.N., andLiou, S.H. (2015)The impact of obstructive sleep apnea on high-sensitivity C-reactive protein in subjects with or without metabolic syndrome. Sleep Breath. 19, 1449–1457

16. Gold, E. B., Wells, C., and Rasor, M. O. (2016) The association of inflammation with premenstrual symptoms. J. Womens Health (Larchmt) 25, 865–874

17. Park, K.H., Zaichenko, L., Peter, P.,Davis, C.R.,Crowell, J.A., and Mantzoros, C. S. (2014) Diet quality is associated with circulating C-reactive protein but not irisin levels in humans. Metabolism 63, 233–241

18. Eltzschig,H.K., andCarmeliet, P. (2011)Hypoxia and inflammation. N. Engl. J. Med. 364, 656–665

19. Heffner, K. L., Waring, M. E., Roberts, M. B., Eaton, C. B., and Gramling,R. (2011) Social isolation,C-reactive protein, and coronary heart disease mortality among community-dwelling adults. Soc. Sci. Med. 72, 1482–1488

20. Shankar, A., McMunn, A., Banks, J., and Steptoe, A. (2011) Loneliness, social isolation, and behavioral and biological health indicators in older adults. Health Psychol. 30, 377–385

21. Eaker,E.D., Sullivan,L.M., Kelly-Hayes,M.,D’Agostino,R.B., Sr., and Benjamin, E. J. (2007) Marital status, marital strain, and risk of coronary heart disease or total mortality: the Framingham Offspring Study. Psychosom. Med. 69, 509–513

22. Rodier, F., and Campisi, J. (2011) Four faces of cellular senescence. J. Cell Biol. 192, 547–556

23. Cevenini, E., Monti, D., and Franceschi, C. (2013) Inflamm-ageing. Curr. Opin. Clin. Nutr. Metab. Care 16, 14–20

24. Jacob, F. (1977) Evolution and tinkering. Science 196, 1161–1166

25. Kushner, I. (2015) Claude Bernard: a failed playwright. Pharos Alpha Omega Alpha Honor Med. Soc. 78, 22–28

26. Karin, M., and Clevers, H. (2016) Reparative inflammation takes charge of tissue regeneration. Nature 529, 307–315

27. Chovatiya, R., and Medzhitov, R. (2014) Stress, inflammation, and defense of homeostasis. Mol. Cell 54, 281–288

28. Artis, D., and Spits, H. (2015) The biology of innate lymphoid cells. Nature 517, 293–301

29. Wang, M., and Kaufman, R. J. (2016) Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529, 326–335

30. Hotamisligil, G. S. (2006) Inflammation and metabolic disorders. Nature 444, 860–867

31. Chaudhari,N.,Talwar, P., Parimisetty,A., Lefebvre d’Hellencourt,C., and Ravanan, P. (2014) A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress. Front. Cell. Neurosci. 8, 213

32. Gregor,M. F., and Hotamisligil, G. S. (2007) Thematic review series: adipocyte biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J. Lipid Res. 48, 1905–1914

33. Misra, J., Chanda, D., Kim, D. K., Cho, S. R., Koo, S. H., Lee, C. H., Back, S. H., and Choi, H. S. (2014) Orphan nuclear receptor Errg induces C-reactive protein gene expression through induction of ERbound Bzip transmembrane transcription factorCREBH. PLoSOne 9, e86342 [Erratum]

34. Shin, D. Y.,Chung, J., Joe, Y.,Pae,H.O.,Chang,K.C.,Cho,G. J.,Ryter, S. W., and Chung, H. T. (2012) Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways. Blood 119, 2523–2532

35. Zhang, K., Shen, X.,Wu, J., Sakaki, K., Saunders, T., Rutkowski, D. T., Back, S. H., and Kaufman, R. J. (2006) Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124, 587–599

36. Zhang, C., Wang, G., Zheng, Z., Maddipati, K. R., Zhang, X., Dyson, G., Williams, P., Duncan, S. A., Kaufman, R. J., and Zhang, K. (2012) Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology 55, 1070–1082

37. Zhang, K., and Kaufman, R. J. (2008) From endoplasmic reticulum stress to the inflammatory response. Nature 454, 455–462

38. Okin, D., and Medzhitov, R. (2012) Evolution of inflammatory diseases. Curr. Biol. 22, R733–R740

39. Kotas, M. E., and Medzhitov, R. (2015)Homeostasis, inflammation, and disease susceptibility. Cell 160, 816–827

40. Rasheed,H., McKinney,C., Stamp, L. K., Dalbeth,N., Topless, R. K., Day, R., Kannangara, D.,Williams, K., Smith, M., Janssen,M., Jansen, T. L., Joosten, L. A., Radstake, T. R., Riches, P. L., Tausche, A. K., Liot´e, F., Lu, L., Stahl, E. A., Choi, H. K., So, A., andMerriman, T. R. (2016) The Toll-Like Receptor 4 (TLR4) variant rs2149356 and risk of gout in European and Polynesian sample sets. PLoS One 11, e0147939

41. Medzhitov, R. (2008)Origin and physiological roles of inflammation. Nature 454, 428–435



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