Alcance de un problema ignorado en el modelo tradicional | 12 DIC 16

Hiperinsulinemia, resistencia a la insulina y enfermedades crónicas

Un vínculo con una causa común subyacente a muchas enfermedades crónicas del presente
Autor/a: Jason Fung, Amy Berger Journal of Insulin Resistance
INDICE:  1. Página 1 | 2. Página 1
Página 1
  1. Mattson MP. Neuroprotective signaling and the aging brain: Take away my food and let me run. Brain Res. 2000;886(1–2):47–53.
  2. O’Keefe JH Jr, Cordain L. Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: How to become a 21st-century hunter-gatherer. Mayo Clin Proc. 2004;79(1):101–108.
  3. Abuissa H, O’Keefe JH Jr, Cordain L. Realigning our 21st century diet and lifestyle with our hunter-gatherer genetic identity. Directions Psych. 2005;25:SR1–SR10.
  4. Reaven GM. Insulin resistance, the insulin resistance syndrome, and cardiovascular disease. Panminerva Med. 2005;47(4):201–210.
  5. Seneff S, Wainwright G, Mascitelli L. Nutrition and Alzheimer’s disease: The detrimental role of a high carbohydrate diet. Eur J Intern Med. 2011;22(2):134–140.
  6. Henderson S. High carbohydrate diets and Alzheimer’s disease. Med Hypotheses. 2004;62:689–700.
  7. Lane RM, Farlow MR. Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer’s disease. J Lipid Res. 2005;46(5):949–968.
  8. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: A disease of Western civilization. Arch Dermatol. 2002;138(12):1584–1590.
  9. Berra B, Rizzo AM. Glycemic index, glycemic load: New evidence for a link with acne. J Am Coll Nutr. 2009;28 (Suppl. 4):450S–454S.
  10. Muscelli E, Natali A, Bianchi S, et al. Effect of insulin on renal sodium and uric acid handling in essential hypertension. Am J Hypertens. 1996;9(8):746–752.
  11. Li C, Hsieh MC, Chang SJ. Metabolic syndrome, diabetes, and hyperuricemia. Curr Opin Rheumatol. 2013;25(2):210–216.
  12. Gheita TA, El-Fishawy HS, Nasrallah MM, Hussein H. Insulin resistance and metabolic syndrome in primary gout: Relation to punched-out erosions. Int J Rheum Dis. 2012;15(6):521–525.
  13. Yao F, Liu L, Zhang Y, et al. Erectile dysfunction may be the first clinical sign of insulin resistance and endothelial dysfunction in young men. Clin Res Cardiol. 2013;102(9):645–651.
  14. Cordain L, Eades MR, Eades MD. Hyperinsulinemic diseases of civilization: More than just Syndrome X. Comp Biochem Physiol A Mol Integr Physiol. 2003;136(1):95–112.
  15. Kraft JR. Hyperinsulinemia: The common denominator of subjective idiopathic tinnitus and other idiopathic central and peripheral neurootologic disorders. Int Tinnitus J. 1995;1(1):46–53.
  16. Mangabeira Albernaz PL, Fukuda Y. Glucose, insulin and inner ear pathology. Acta Otolaryngol. 1984;97(5–6):496–501.
  17. D’Avila C, Lavinsky L. Glucose and insulin profiles and their correlations in Ménière’s disease. Int Tinnitus J. 2005;11(2):170–176.
  18. American Diabetes Association. Fast facts. Data and statistics about diabetes [homepage on the Internet]. [cited 2016 Feb 9]. Available from: - Sean/Documents/Fast_Facts_12-2015a.pdf
  19. United States Centers for Disease Control and Prevention (CDC). 2014 National diabetes NStatistics report. Estimates of diabetes and its burden in the United States [homepage on the Internet]. [cited 2016 Feb 9]. Available from:
  20. Alzheimer’s Association. 2015 Alzheimer’s disease facts and figures [homepage on the Internet]. [cited 2016 Jan 22]. Available from:
  21. Crofts C, Zinn C, Wheldon M, Schofield G. Hyperinsulinemia: A unifying theory of chronic disease? Diabesity. 2015;1(4):34–43.
  22. National Institutes of Health. National Institute of Diabetes and Digestive and Kidney Diseases. Diagnosis of diabetes and prediabetes [homepage on the Internet]. [cited 2016 Feb 9]. Available from:
  23. Kraft JR. Diabetes epidemic & you. Victoria, Canada: Trafford Publishing; 2008.
  24. Kraft JR, Wehrmacher WH. Diabetes – A silent disorder. Compr Ther. 2009 Fall–Winter;35(3–4):155–159.
  25. Volek JS, Feinman RD. Carbohydrate restriction improves the features of metabolic syndrome. Metabolic syndrome may be defined by the response to carbohydrate restriction. Nutr Metab. 2005;2:31.
  26. Reaven GM. Why Syndrome X? From Harold Himsworth to the insulin resistance syndrome. Cell Metab. 2005;1(1):9–14.
  27. Reaven GM. The insulin resistance syndrome: Definition and dietary approaches to treatment. Annu Rev Nutr. 2005;25:391–406.
  28. National Institutes of Health. National Heart, Lung, and Blood Institute. What is metabolic syndrome? [homepage on the Internet]. [cited 2016 Feb 9]. Available from:
  29. Mossmann M, Wainstein MV, Gonçalves SC, et al. HOMA-IR is associated with significant angiographic coronary artery disease in non-diabetic, non-obese individuals: A cross-sectional study. Diabetol Metab Syndr. 2015;7:100.
  30. Reaven GM, Chen YD, Jeppesen J, Maheux P, Krauss RM. Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles. J Clin Invest. 1993;92(1):141–146.
  31. Ndumele CE, Pradhan AD, Ridker PM. Interrelationships between inflammation, C-reactive protein, and insulin resistance. J Cardiometab Syndr. 2006 Summer;1(3):190–196.
  32. Bonnet F, Ducluzeau P-H, Gastaldelli A, et al. Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women. Diabetes. 2011;60(6):1660–1667.
  33. Phillips CM, Dillon C, Harrington JM, et al. Defining metabolically healthy obesity: Role of dietary and lifestyle factors. Atkin SL, ed. PLoS One. 2013;8(10):e76188.
  34. Oliveros E, Somers VK, Sochor O, et al. The concept of normal weight obesity. Progr Cardiovasc Dis. 2014;56(4):426–433.
  35. Romero-Corral A, Somers VK, Sierra-Johnson J, et al. Normal weight obesity: A risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J. 2010;31(6):737–746.
  36. Voulgari C, Tentolouris N, Dilaveris P, et al. Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals. J Am Coll Cardiol. 2011;58(13):1343–1350.
  37. Kim M, Paik JK, Kang R. Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight/obese individuals. Metabolism. 2013;62(4):554–560.
  38. Matos LN, Giorelli Gde V, Dias CB. Correlation of anthropometric indicators for identifying insulin sensitivity and resistance. Sao Paulo Med J. 2011;129(1):30–35.
  39. Goto A, Noda M, Matsushita Y, et al. Hemoglobin A1c Levels and the risk of cardiovascular disease in people without known diabetes: A population-based cohort study in Japan. Zrelak P, ed. Medicine. 2015;94(17):e785.
  40. Ikeda F, Doi Y, Ninomiya T, et al. Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: The Hisayama Study. Cardiovasc Diabetol. 2013;12:164.
  41. Khaw KT, Wareham N, Bingham S, et al. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: The European prospective investigation into cancer in Norfolk. Ann Intern Med. 2004;141(6):413–420.
  42. American Diabetes Association. Standards of medical care in diabetes – 2012. Diabetes Care. 2012;35(Suppl 1):S11–S63.
  43. Pai JK, Cahill LE, Hu FB, Rexrode KM, Manson JE, Rimm EB. Hemoglobin A1c is associated with increased risk of incident coronary heart disease among apparently healthy, nondiabetic men and women. J Am Heart Assoc. 2013;2(2):e000077.
  44. Seyfried TN, Flores RE, Poff AM, D’Agostino DP. Cancer as a metabolic disease: Implications for novel therapeutics. Carcinogenesis. 2014;35(3):515–527.
  45. Mathupala SP, Ko YH, Pedersen PL. The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies. Biochim Biophys Acta. 2010;1797(6–7):1225–1230.
  46. Mathupala SP, Ko YH, Pedersen PL. Hexokinase-2 bound to mitochondria: Cancer’s stygian link to the ‘Warburg effect’ and a pivotal target for effective therapy. Semin Cancer Biol. 2009;19(1):17–24.
  47. Mathupala SP, Rempel A, Pedersen PL. Aberrant glycolytic metabolism of cancer cells: A remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase. J Bioenerg Biomembr. 1997;29(4):339–343.
  48. Klement RJ, Kämmerer U. Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutr Metab. 2011;8:75.
  49. Nowak K, Eldredge-Hindy H,


Para ver los comentarios de sus colegas o para expresar su opinión debe ingresar con su cuenta de IntraMed.

Términos y condiciones de uso | Política de privacidad | Todos los derechos reservados | Copyright 1997-2024