Secuelas orgánicas y funcionales | 26 JUL 22

Interacción intestino-cerebro en el síndrome post COVID-19

Incidencia, fisiopatología mecanismos de los cuadros digestivos y probable manejo
Autor/a: Rithvik Golla, Sudheer Kumar Vuyyuru, Bhaskar Kante, Saurabh Kedia, Vineet Ahuja Postgraduate Medical Journal Published Online First: 01 July 2022.
INDICE:  1. Texto principal | 2. Referencia bibliográfica
Referencia bibliográfica

1 Karia R, Gupta I, Khandait H, et al. COVID-19 and its modes of transmission. SN Compr Clin Med 2020;2:1798–801.

2 Parasa S, Desai M, Thoguluva Chandrasekar V, et al. Prevalence of gastrointestinal symptoms and fecal viral shedding in patients with coronavirus disease 2019: a systematic review and meta-analysis. JAMA Netw Open 2020;3:e2011335.

3 Cheung KS, Hung IFN, Chan PPY, et al. Gastrointestinal manifestations of SARS-CoV-

2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis. Gastroenterology 2020;159:81–95.

4 Tariq R, Saha S, Furqan F, et al. Prevalence and mortality of COVID-19 patients with gastrointestinal symptoms: a systematic review and meta-analysis. Mayo Clin Proc 2020;95:1632–48.

5 Mao R, Qiu Y, He J-S, et al. Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2020;5:667–78.

6 Schmulson M, Ghoshal UC, Barbara G. Managing the inevitable surge of Post-COVID-19 functional gastrointestinal disorders. Am J Gastroenterol 2021;116:4–7.

7 Shah W, Hillman T, Playford ED, et al. Managing the long term effects of covid-19: summary of NICE, sign, and RCGP rapid guideline. BMJ 2021;372:n136.

8 CDC. COVID-19 and your health. centers for disease control and prevention. Available: [Accessed 31 Dec 2021].

9 Kunal S, Madan M, Tarke C. Emerging spectrum of post-COVID- 19 syndrome. Postgrad Med J 2021. [Epub ahead of print: 08 Dec 2021].

10 Cui J, Li F, Shi Z-L. Origin and evolution of pathogenic coronaviruses. Nat Rev

11 Baker SJ, Mathan M, Mathan VI, et al. Chronic enterocyte infection with coronavirus. one possible cause of the syndrome of tropical sprue? Dig Dis Sci 1982;27:1039–43.

12 Xu J, Chu M, Zhong F, et al. Digestive symptoms of COVID-19 and expression of ACE2 in digestive tract organs. Cell Death Discov 2020;6:76.

13 COVID-19 Investigation Team. Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States. Nat Med 2020;26:861–8.

14 Wu Y, Guo C, Tang L, et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet Gastroenterol Hepatol 2020;5:434–5.

15 Joukar F, Yaghubi Kalurazi T, Khoshsorour M, et al. Persistence of SARS-CoV-2 RNA in the nasopharyngeal, blood, urine, and stool samples of patients with COVID-19: a hospital-based longitudinal study. Virol J 2021;18:134.

16 Xu CLH, Raval M, Schnall JA, et al. Duration of respiratory and gastrointestinal viral shedding in children with SARS-CoV-2: a systematic review and synthesis of data. Pediatr Infect Dis J 2020;39:e249–56.

17 Lin W, Xie Z, Li Y, et al. Association between detectable SARS-COV-2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019. J Med Virol 2021;93:794–802.

18 Liu J, Xiao Y, Shen Y, et al. Detection of SARS-CoV-2 by RT-PCR in anal from patients who have recovered from coronavirus disease 2019. J Med Virol 2020;92:1769–71.

19 Huang Y, Chen S, Yang Z, et al. SARS-CoV-2 viral load in clinical samples from critically ill patients. Am J Respir Crit Care Med 2020;201:1435–8.

20 Han C, Duan C, Zhang S, et al. Digestive symptoms in COVID-19 patients with mild disease severity: clinical presentation, stool viral RNA testing, and outcomes. Am J Gastroenterol 2020;115:916-923.

21 Lo IL, Lio CF, Cheong HH, et al. Evaluation of SARS-CoV- 2

RNA shedding in Clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau. Int J Biol Sci 2020;16:1698–707.

22 Zhao F, Yang Y, Wang Z, et al. The time sequences of respiratory and rectal viral shedding in patients with coronavirus disease 2019. Gastroenterology 2020;159:1158–60.

23 Chen Y, Chen L, Deng Q, et al. The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients. J Med Virol 2020;92:833–40.

24 Schmulson M, Dávalos MF, Berumen J. Beware: gastrointestinal symptoms can be a manifestation of COVID-19. Rev Gastroenterol Mex 2020;85:282–7.

25 Rokkas T. Gastrointestinal involvement in COVID-19: a systematic review and meta-analysis. Ann Gastroenterol 2020;33:355–65.

26 Budden KF, Gellatly SL, Wood DLA, et al. Emerging pathogenic links between microbiota and the gut-lung axis. Nat Rev Microbiol 2017;15:55–63.

27 de Oliveira GLV, Oliveira CNS, Pinzan CF, et al. Microbiota modulation of the Gut-Lung axis in COVID-19. Front Immunol 2021;12:635471.

28 Roussos A, Koursarakos P, Patsopoulos D, et al. Increased prevalence of irritable bowel syndrome in patients with bronchial asthma. Respir Med 2003;97:75–9.

29 Rutten EPA, Lenaerts K, Buurman WA, et al. Disturbed intestinal integrity in patients with COPD: effects of activities of daily living. Chest 2014;145:245–52.

30 Bradley KC, Finsterbusch K, Schnepf D, et al. Microbiota-Driven tonic interferon signals in lung stromal cells protect from influenza virus infection. Cell Rep 2019;28:245–56.

31 McAleer JP, Kolls JK. Maintaining poise: commensal microbiota calibrate interferón responses. Immunity 2012;37:10–12.

32 Ichinohe T, Pang IK, Kumamoto Y, et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A 2011;108:5354–9.

33 Panwar RB, Sequeira RP, Clarke TB. Microbiota-mediated protection against antibiotic-resistant pathogens. Genes Immun 2021;22:255–67.

34 Frontiers. Respiratory antiviral immunity and Immunobiotics: beneficial effects on Inflammation-Coagulation interaction during influenza virus infection | immunology. Available: [Accessed 11 Jan 2022].

35 Nature Medicine. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Available: [Accessed 11 Jan 2022].

36 Baud D, Dimopoulou Agri V, Gibson GR, et al. Using probiotics to Flatten the curve of coronavirus disease COVID-2019 pandemic. Front Public Health 2020;8:186.

37 Chaudhary NA, Truelove SC. The irritable colon syndrome. A study of the Clinical features, predisposing causes, and prognosis in 130 cases. Q J Med 1962;31:307–22.

38 Thabane M, Kottachchi DT, Marshall JK. Systematic review and meta-analysis: the incidence and prognosis of post-infectious irritable bowel syndrome. Aliment Pharmacol Ther 2007;26:535–44.

39 Barbara G, Grover M, Bercik P, et al. Rome Foundation working team report on Post-Infection irritable bowel syndrome. Gastroenterology 2019;156:46–58.



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