No siempre a cada síntoma le corresponde un daño | 03 FEB 19

Síntomas, placebo y cerebro bayesiano

A pesar de su éxito, el modelo biomédico no ha proporcionado una explicación adecuada de dos fenómenos bien demostrado: los síntomas sin alteración fisiopatológica y el alivio después de la administración de un placebo.
Autor: Ongaro, Giulioa, Kaptchuk, Ted J. Fuente: Pain: doi: 10.1097/j.pain.0000000000001367 Topical Review Symptom perception, placebo effects, and the Bayesian brain Ongaro, Giulioa,*; Kaptchuk, Ted J.b,c
INDICE:  1. Página 1 | 2. Referencias bibliográficas
Referencias bibliográficas
  1. Anchisi D, Zanon MA. Bayesian perspective on sensory and cognitive integration in pain perception and placebo analgesia. PLoS One 2015;10:e0117270.
  2. Barrett LF, Simmons WK. Interoceptive predictions in the brain. Nat Rev Neurosci 2015;16:419–29.
  3. Benedetti F, Lanotte M, Lopiano L, Colloca L. When words are painful: unraveling the mechanisms of the nocebo effect. Neuroscience 2007;147:260–71.
  4. enedetti F, Maggi G, Lopiano L, Lanotte M, Rainero I, Vighetti S, Pollo A. Open versus hidden medical treatments: the patient's knowledge about a therapy affects the therapy outcome. Prev Treat 2003;6:1a.
  5. Benedetti F, Carlino E, Pollo A. Hidden administration of drugs. Clin Pharmacol Ther 2011;90:651–61.
  6. Brown H, Adams RA, Parees I, Edwards M, Friston K. Active inference, sensory attenuation and illusions. Cogn Process 2013;14:411–27.
  7. Büchel C, Geuter S, Sprenger C, Eippert F. Placebo analgesia: a predictive coding perspective. Neuron 2014;81:1223–39.
  8. Carvalho C, Caetano JM, Cunha L, Rebouta P, Kaptchuk TJ, Kirsch I. Open-label placebo treatment in chronic low back pain: a randomized controlled trial. PAIN 2016;157:2766.
  9. Clark A. Whatever next? Predictive brains, situated agents, and the future of cognitive science. Behav Brain Sci 2013;36:181–204.
  10. Clark A. Surfing uncertainty: prediction, action, and the embodied mind. Oxford: Oxford University Press, 2015.
  11. Colagiuri B, Quinn VF, Colloca L. Nocebo hyperalgesia, partial reinforcement, and extinction. J Pain 2015;16:995–1004.
  12. Colloca L, Benedetti F. Placebo analgesia induced by social observational learning. PAIN 2009;144:28–34.
  13. Edwards MJ, Adams RA, Brown H, Parees I, Friston KJ. A Bayesian account of “hysteria”. Brain 2012;135:3495–512.
  14. Espay AJ, Norris MM, Eliassen JC, Dwivedi A, Smith MS, Banks C, Allendorfer JB, Lang AE, Fleck DE, Linke MJ, Szaflarski JP. Placebo effect of medication cost in Parkinson disease a randomized double-blind study. Neurology 2015;84:794–802.
  15. Friston K, Shiner T, Fitzgerald T, Galea JM, Adams R, Brown H, Dolan RJ, Moran R, Stephan KE, Bestmann S. Dopamine, affordance and active inference. PLoS Comput Biol 2012;8:e1002327.
  16. Geuter S, Koban L, Wager TD. The cognitive neuroscience of Placebo effects: concepts, predictions, and physiology. Annu Rev Neurosci 2017;40:167–88.
  17. Grahl A, Onat S, Büchel C. The periaqueductal gray and Bayesian integration in placebo analgesia. Elife 2018;7:e32930.
  18. Hechler T, Endres D, Thorwart A. Why harmless sensations might hurt in individuals with chronic pain: about heightened prediction and perception of pain in the mind. Front Psychol 2016;7:1638.
  19. Hohwy J. The predictive mind. Oxford: Oxford University Press, 2013.
  20. Jensen KB, Kaptchuk TJ, Kirsch I, Raicek J, Lindstrom KM, Berna C, Gollub RL, Ingvar M, Kong J. Nonconscious activation of placebo and nocebo pain responses. Proc Natl Acad Sci 2012;109:15959–64.
  21. Kam-Hansen S, Jakubowski M, Kelley JM, Kirsch I, Hoaglin DC, Kaptchuk TJ, Burstein R. Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci Transl Med 2014;6:218ra5.
  23. Kaptchuk TJ. Open-label placebos: reflections on a research agenda. Perspect Biol Med 2018;61:311–34.
  25. Kaptchuk TJ, Kelley JM, Conboy LA, Davis RB, Kerr CE, Jacobson EE, Kirsch I, Schyner RN, Nam BH, Nguyen LT, Park M. Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ 2008;336:999–1003.
  26. Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN, Kokkotou E, Singer JP, Kowalczykowski M, Miller FG, Kirsch I, Lembo AJ. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One 2010;5:e15591.
  27. Seth AK, Suzuki K, Critchley HD. An interoceptive predictive coding model of conscious presence. Front Psychol 2012;2:395.
  29. Tenenbaum JB, Kemp C, Griffiths TL, Goodman ND. How to grow a mind: statistics, structure, and abstraction.
  30. Van den Bergh O, Brown RJ, Petersen S, Witthöft M. Idiopathic environmental intolerance: a comprehensive model. Clin Psychol Sci 2017;5:551–67.
  32. Van den Bergh O, Witthöft M, Petersen S, Brown RJ. Symptoms and the body: taking the inferential leap. Neurosci Biobehav Rev 2017;74:185–203.
  33. Wechsler ME, Kelley JM, Boyd IO, Dutile S, Marigowda G, Kirsch I, Israel E, Kaptchuk TJ. Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N Engl J Med 2011;365:119–26.
  34. Wiech K. Deconstructing the sensation of pain: the influence of cognitive processes on pain perception. Science 2016;354:584–7.
  36. Wilkinson S. Accounting for the phenomenology and varieties of auditory verbal hallucination within a predictive processing framework. Conscious Cogn 2014;30:142–55.
  37. Zaman J, Vlaeyen JW, Van Oudenhove L, Wiech K, Van Diest I. Associative fear learning and perceptual discrimination: a perceptual pathway in the development of chronic pain. Neurosci Biobehav Rev 2015;51:118–25.


Usted debe ingresar al sitio con su cuenta de usuario IntraMed para ver los comentarios de sus colegas o para expresar su opinión. Si ya tiene una cuenta IntraMed o desea registrase, ingrese aquí