Una causa tratable de EPOC | 05 DIC 16

Deficiencia de Alfa-1 Antitripsina

Es un trastorno genético común pero subdiagnosticado, que aumenta el riesgo de EPOC y enfermedad hepática.
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1. Laurell C, Eriksson A. The electrophoretic alpha-1 globulin pattern of serum in alpha-1 antitrypsin deficiency. Scand J Clin Lab Invest 1963; 15:132–140.

2. Aboussouan LS, Stoller JK. Detection of alpha-1 antitrypsin deficiency: a review. Respir Med 2009; 103:335–341.

3. Stoller JK, Brantly M. The challenge of detecting alpha-1 antitrypsin deficiency. COPD 2013; 10(suppl 1):26–34.

4. Stoller JK, Smith P, Yang P, Spray J. Physical and social impact of alpha 1-antitrypsin deficiency: results of a survey. Cleve Clin J Med 1994; 61:461–467.

5. Stoller JK, Sandhaus RA, Turino G, Dickson R, Rodgers K, Strange C. Delay in diagnosis of alpha1-antitrypsin deficiency: a continuing problem. Chest 2005; 128:1989–1994.

6. Campos MA, Wanner A, Zhang G, Sandhaus RA. Trends in the diagnosis of symptomatic patients with alpha1-antitrypsin deficiency between 1968 and 2003. Chest 2005; 128:1179–1186.

7. Greulich T, Ottaviani S, Bals R, et al. Alpha1-antitrypsin deficiency— diagnostic testing and disease awareness in Germany and Italy. Respir Med 2013; 107:1400–1408.

8. Taliercio RM, Chatburn RL, Stoller JK. Knowledge of alpha-1 antitrypsin deficiency among internal medicine house officers and respiratory therapists: results of a survey. Respir Care 2010; 55:322–327.

9. Rubenfeld GD, Cooper C, Carter G, Thompson BT, Hudson LD. Barriers to providing lung-protective ventilation to patients with acute lung injury. Crit Care Med 2004; 32:1289–1293.

10. Cabana MD, Rand CS, Powe NR, et al. Why don’t physicians follow clinical practice guidelines? A framework for improvement. JAMA 1999; 282:1458–1465.

11. Rahaghi F, Ortega I, Rahaghi N, et al. Physician alert suggesting alpha-1 antitrypsin deficiency testing in pulmonary function test (PFT) results. COPD 2009; 6:26–30.

12. Campos M, Hagenlocker B, Martinez N, et al. Impact of an electronic medical record clinical reminder to improve detection of COPD and alpha-1 antitrypsin deficiency in the Veterans Administration (VA) system (abstract). Am J Respir Crit Care Med 2011; 183:A5356.


A5356. Accessed May 24, 2016.

13. Jain A, McCarthy K, Xu M, Stoller JK. Impact of a clinical decision support system in an electronic health record to enhance detection of alpha(1)-antitrypsin deficiency. Chest 2011; 140:198–204.

14. American Thoracic Society, European Respiratory Society. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1antitrypsin deficiency. Am J Respir Crit Care Med 2003; 168:818–900.

15. Rahaghi FF, Sandhaus RA, Brantly ML, et al. The prevalence of alpha-1 antitrypsin deficiency among patients found to have airflow obstruction. COPD 2012; 9:352–358.

16. Carrell RW, Lomas DA. Alpha1-antitrypsin deficiency—a model for conformational diseases. N Engl J Med 2002; 346:45–53.

17. Stoller JK, Aboussouan LS. A review of alpha1-antitrypsin deficiency. Am J Respir Crit Care Med 2012; 185:246–259.

18. McElvaney NG, Stoller JK, Buist AS, et al. Baseline characteristics of enrollees in the National Heart, Lung and Blood Institute Registry of Alpha 1-Antitrypsin Deficiency. Alpha 1-Antitrypsin Deficiency Registry Study Group. Chest 1997; 111: 394–403.

19. Lomas DA, Evans DL, Finch JT, Carrell RW. The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature 1992; 357: 605–607.



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