Interrelación entre factores genéticos y ambientales | 24 ENE 07

Patogenia del tromboembolismo venoso

El riesgo de tromboembolismo asociado con deficiencias hereditarias de proteínas S o C, o de antitrombina dependería de la presencia de otros factores trombofílicos y de factores de riesgo exógenos.
Autor/a: Jan-Leendert P. Brouwer; Nic J.G.M. Veeger; Hanneke C. Kluin-Nelemans; Jan van der Meer The Pathogenesis of Venous Thromboembolism: Evidence for Multiple Interrelated Causes. Ann Intern Med. 2006;145:807-815
INDICE:  1. Referencias | 2. Referencias
Referencias

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2. Anderson FA Jr, Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med. 1991;151:933-8.
3. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet. 1999;353: 1167-73.
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5. Zöller B, Berntsdotter A, Garcia de Frutos P, Dahlbäck B. Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S. Blood. 1995;85:3518-23.
6. van Boven HH, Reitsma PH, Rosendaal FR, Bayston TA, Chowdhury V, Bauer KA, et al. Factor V Leiden (FV R506Q) in families with inherited anti-thrombin deficiency. Thromb Haemost. 1996;75:417-21.
7. Koeleman BP, Reitsma PH, Allaart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood. 1994;84:1031-5.
8. Tirado I, Mateo J, Soria JM, Oliver A, Borrell M, Coll I, et al. Contribution of prothrombin 20210A allele and factor V Leiden mutation to thrombosis risk in thrombophilic families with other hemostatic deficiencies. Haematologica. 2001;86:1200-8.
9. Castaman G, Tosetto A, Cappellari A, Ruggeri M, Rodeghiero F. The A20210 allele in the prothrombin gene enhances the risk of venous thrombosis in carriers of inherited protein S deficiency. Blood Coagul  Fibrinolysis. 2000;11:321-6.
10. Vossen CY, Conard J, Fontcuberta J, Makris M, van der Meer FJ, Pabinger I, et al. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost. 2005;3:459-64.
11. Frezzato M, Tosetto A, Rodeghiero F. Validated questionnaire for the identification of previous personal or familial venous thromboembolism. Am J Epidemiol. 1996;143:1257-65.
12. Brouwer JL, Veeger NJ, van der Schaaf W, Kluin-Nelemans HC, van der Meer J. Difference in absolute risk of venous and arterial thrombosis between familial protein S deficiency type I and type III. Results from a family cohort study to assess the clinical impact of a laboratory test-based classification. Br J Haematol. 2005;128:703-10.
13. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369:64-7.
14. Danneberg

 

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