⚠️¿Qué es el síndrome de infusión de propofol (PRIS)?
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El PRIS es una complicación infrecuente pero potencialmente fatal asociada al uso de propofol en infusiones prolongadas (>48 h) o a dosis elevadas (>5 mg/kg/h). Se presenta con: acidosis metabólica grave, hiperkalemia, hiperlipidemia, rabdomiólisis, disfunción hepática, insuficiencia renal y compromiso cardiovascular, junto con alteraciones electrocardiográficas (elevación del ST con patrón tipo Brugada).
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Manejo:
- Suspensión inmediata del propofol.
- Soporte respiratorio según requerimiento.
- Soporte hemodinámico: fluidos y vasopresores.
- Considerar hemofiltración continua precoz y monitoreo de CK, lactato, triglicéridos y electrolitos.
🔗Fuente: The incidence of propofol infusion syndrome in critically-ill patients
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