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22 de octubre de 2025
🎯 FDA APRUEBA IMLUNESTRANT PARA CÁNCER DE MAMA RESISTENTE A TERAPIA HORMONAL
La FDA aprobó imlunestrant para cáncer de mama ER+/HER2-/ESR1-mutado avanzado/metastásico con progresión tras ≥1 línea terapia endocrina.
El estudio EMBER-3 (n=874) encontró:
SLP mediana: 5,5 vs 3,8 meses (HR=0,62; p<0,001)
Reducción 38% riesgo progresión/muerte vs terapia estándar
La Dra. Komal Jhaveri dijo: "La mutación ESR1 está presente en casi el 50% de pacientes tratadas con hormonoterapia, contribuyendo a resistencia terapéutica. Esta nueva opción oral simplifica el tratamiento continuo".
En contexto, hay que considerar que hasta 40 % de los cánceres de mama ER+/HER2- avanzados desarrollan mutación ESR1, generando resistencia a los inhibidores de aromatasa y SERM.
Instituciones sugeridas
Contenido sugerido
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