Ahora, en un estudio publicado en "The New England Journal of Medicine", investigadores norteamericanos muestran que variantes en un gen implicado en la coagulación pueden ayudar a explicar por qué ciertos pacientes requieren una dosis más baja o más alta de warfarina para obtener sus beneficios.
El gen en cuestión es el de la vitamina K epóxido reductasa, que fabrica una proteína que ayuda a controlar la coagulación y que es una diana clave de la warfarina.
Webs Relacionadas
New England Journal of Medicine
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Publicado el 27 de junio de 2005
Anticoagulación
Variantes genéticas y respuesta a la warfarina
Millones de personas en el mundo toman el anticoagulante warfarina para prevenir la formación de trombos tras un infarto de miocardio, un ictus o una operación quirúrgica, pero la dosis correcta del fármaco para cada cual es muy variable y difícil de determinar.
Ahora, en un estudio publicado en "The New England Journal of Medicine", investigadores norteamericanos muestran que variantes en un gen implicado en la coagulación pueden ayudar a explicar por qué ciertos pacientes requieren una dosis más baja o más alta de warfarina para obtener sus beneficios.
El gen en cuestión es el de la vitamina K epóxido reductasa, que fabrica una proteína que ayuda a controlar la coagulación y que es una diana clave de la warfarina.
Webs Relacionadas
New England Journal of Medicine