Basándose en resultados previos con ratones, investigadores de varias universidades estadounidenses analizaron la relación entre las variantes de dicho gen y el control de la glucosa en 811 individuos hispanos. Encontraron 20 variantes en una secuencia específica del PTPN1 que se asociaron de forma significativa a la sensibilidad a la insulina. Otras 22 variantes en otra región del gen se relacionaron con los niveles de glucosa en ayunas.
Según los autores, la diferencia en el riesgo se debe a los niveles o la estabilidad del mensaje del PTPN1 en distintas personas con diferentes variantes del gen.
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Diabetes
http://diabetes.diabetesjournals.org/
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