La investigación es la primera que se publica sobre el desarrollo de una vacuna contra el SRAS y llega pocos meses después de que se identificara el virus causante de la enfermedad y de que su genoma fuera publicado.
En su estudio, inmunizaron a 6 macacos rhesus con una combinación de tres vectores. Otros dos animales se emplearon como controles. A los 28 días, recibieron una segunda inmunización. A las 6 semanas ya se detectaron linfocitos T y anticuerpos contra el virus del SRAS en todos los macacos vacunados, pero en ninguno de los controles. La intensidad de la respuesta varió entre los animales, pero generalmente fue prolongada tras la dosis de recuerdo. Las muestras de sangre obtenidas de los animales inmunizados mostraron en el laboratorio una potente capacidad para neutralizar el virus.
Los investigadores planean ahora ensayar la vacuna en hurones, animales que pueden ser infectados por el coronavirus del SRAS y, en el caso de mostrarse efectiva, se podría ensayar dentro de unos meses en humanos.
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