Para el estudio, se seleccionaron 550 mujeres. Después de completar tres ciclos de quimioterapia tras la intervención, 216 pacientes que reunían los requisitos fueron asignadas aleatoriamente a recibir citorreducción quirúrgica secundaria seguida por quimioterapia y 208 recibieron quimioterapia sola. La cirugía fue rechazada o estaba contraindicada médicamente en 15 pacientes de las que fueron asignadas a cirugía secundaria, lo que representa un 17% de las evaluadas.
En marzo de 2003, 296 pacientes habían fallecido y 82 presentaban progresión de la enfermedad. Los datos del estudio ponen de manifiesto que la probabilidad de supervivencia sin progresión en el grupo asignado a la cirugía secundaria más quimioterapia, comparado con el grupo de quimioterapia solamente, fue de 1,07 y el riesgo relativo de muerte fue de 0,99.
Normalmente, el cáncer de ovario aparece en fase avanzada. En estos momentos, además de nuevos citostáticos, se investiga en aproximaciones de riesgo genético que podrían ser útiles para el desarrollo de estrategias de carácter preventivo.
Webs Relacionadas
Case Western Reserve University
http://www.cwru.edu/
New England Journal of Medicine
http://content.nejm.org/
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