Se trata de un estudio de tres años de duración cuyos resultados indican que aquellos pacientes que reciben paricalcitol presentan 16% más probabilidades de supervivencia en dicho período que aquellos que reciben calcitriol.
Para los autores, se trata de la primera evidencia de que una forma específica de vitamina D es capaz de variar la tasa de mortalidad en pacientes renales en diálisis.
Se estima que la mortalidad en estos enfermos es del 20% anual. Aunque se han ensayado distintas estrategias para disminuir este alto porcentaje, muy pocas han obtenido resultados prometedores. La vitamina D se utiliza para tratar el desequilibrio del metabolismo óseo y mineral que se deriva de la insuficiencia renal.
En el nuevo estudio se llevó a cabo el seguimiento de unos 67.000 pacientes que comenzaron a recibir vitamina D intravenosa a partir de 1999. Además de constatar esa disminución del riesgo de muerte del 16% entre los que recibieron paricalcitol, los autores subrayan que la reducción fue más evidente en los pacientes de raza negra y en los diabéticos. Además, los participantes que cambiaron de calcitriol a paricalcitol vivieron más tiempo que los tratados inicialmente con la nueva formulación que pasaron a recibir la convencional.
Webs Relacionadas
Massachusetts General Hospital
http://www.mgh.harvard.edu/
New England Journal of Medicine
http://content.nejm.org/
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