En sus experimentos con peces cebra han comprobado que la ausencia del gen de la troponina T conduce a la expresión reducida de otras proteínas necesarias para la formación del sarcómero, la unidad fundamental de contracción del corazón. Por lo tanto, se trata de la primera investigación que muestra que dicha proteína es esencial para que el corazón lata adecuadamente.
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University of California, San Francisco
http://www.ucsf.edu/
Nature Genetics
http://www.nature.com/ng/
Medical News
/ Published on May 2, 2002
Miocardiopatía
Un nuevo estudio arroja nueva luz al mecanismo de la miocardiopatía hipertrófica
La principal causa de muerte súbita en atletas jóvenes es la miocardiopatía hipertrófica, enfermedad que puede desarrollarse a partir de una mutación en el gen de la troponina T, la cual interrumpe la acción de otros dos genes, interfiriendo en el latido del corazón. Investigadores de la Universidad de California en San Francisco (Estados Unidos) explican en "Nature Genetics" que esos tres genes codifican proteínas contráctiles que interactúan con el músculo cardíaco.
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