Esta investigación sugiere nuevas formas de incrementar la efectividad de los trasplantes de médula ósea de donantes emparentados y no emparentados para el tratamiento de cánceres, deficiencias genéticas y enfermedades autoinmunes.
En los roedores el gen SHIP parece desempeñar un papel crucial para que el organismo distinga entre el tejido propio y el ajeno. Cuando este gen está desactivado el sistema inmunitario no reconoce la médula ósea de un donante como sustancia ajena y permite así que el injerto sobreviva.
Si este gen desempeña el mismo papel en el ser humano –algo que aún está por demostrar- podrían desarrollarse fármacos que bloquearan el SHIP temporalmente y que se administrarían a pacientes antes de someterse al trasplante, destacan los autores.
Webs Relacionadas
University of South Florida
http://www.usf.edu/
Science
http://www.sciencemag.org/
Moffitt Cancer Center and Research Institute
http://www.moffitt.usf.edu/
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