Según los autores, de Eli Lilly, estas mejoras tienen lugar sin que produzcan cambios en los depósitos de amiloide que caracterizan la enfermedad.
En este sentido, señalan que la placa de amiloide no parece ser la culpable de ciertos tipos de pérdida de memoria, pues este síntoma puede mejorarse sin reducir los depósitos.
El fármaco ensayado es un anticuerpo monoclonal. Estudios previos mostraban que la sustancia, administrada en dosis repetidas, previene la formación de placas de amiloide en el cerebro. En el nuevo experimento, administraron una sola dosis del anticuerpo, llamado m266, a ratones con gran cantidad de depósitos de amiloide. Los roedores tratados fueron capaces de funcionar como ratones normales en dos tipos de pruebas de memoria.
Webs Relacionadas
Nature Neuroscience
http://www.nature.com/
Eli Lilly
http://www.lilly.com/
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