Los autores, del University of Texas M.D. Anderson Cancer Center, en Houston, hicieron análisis genéticos a .1270 varones mujeres con y sin cáncer de pulmón (el 90% eran fumadores), y encontraron que variantes particulares en el p53 están asociadas a un riesgo aumentado de la enfermedad. Estas variantes, según muestran, son más frecuentes en la población de raza negra y menos entre las personas de origen mexicano, lo que explica las diferencias observadas en las respectivas tasas de incidencia del cáncer pulmonar en ambas etnias.
Los autores estudiaron tres variantes en tres lugares específicos del gen p53, y encontraron que las tres se asocian a un aumento del riesgo. El 29% de las personas de raza negra era portador de alguna de las variantes, frente al 12% de las de origen mexicano y al 14% de las de raza blanca.
Webs Relacionadas
MD Anderson Cancer Center
http://www.mdanderson.org/
Journal of the National Cancer Institute
http://jncicancerspectrum.oupjournals.org/
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