Fumadores sanos muestran cambios en la composición de sus lágrimas que se parece a las de los pacientes con oftalmopatía de Graves, según informa “Archives of Ophthalmology”.
Especialistas de la Cardiff University (Reino Unido) compararon la composición de las lágrimas de 37 no fumadores, 33 fumadores sanos, 51 pacientes con enfermedad de Graves y 85 pacientes con oftalmopatía de Graves de diferentes grados de gravedad.
En el 25% de las muestras de lágrimas de los fumadores sanos, en el 32% de las de pacientes con enfermedad de Graves, y en el 41% de las de pacientes con oftalmopatía de Graves, los autores hallaron una estimulación específica de los receptores de tirotropina. Además, encontraron proteínas adicionales en pacientes con oftalmopatía de Graves y en fumadores sanos, en comparación con no fumadores.
El incremento de la expresión y el peso molecular modificado de estas proteínas parecen indicar que se producen degradación y cambios durante la glucosilación, lo que puede afectar a la bioactividad.
Los autores subrayan que fumar es un significativo factor de riesgo para desarrollar oftalmopatía de Graves.
Archives of Ophthalmology 2006;124:1451-1456
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