La vacuna (denominada AutoVac) se ha elaborado con dos pequeños fragmentos inactivos derivados de la toxina del tétanos. Actúa poniendo en marcha la respuesta inmune de la mujer para que ayude a los linfocitos T a atacar el tumor y a producir anticuerpos HER-2. El sistema inmune, entonces, reconocerá la sobreexpresión de HER-2 de las células cancerigenas y las atacará. En cambio, ignorará la proteína HER-2 de los tejidos sanos, ya que en ellos los niveles son muy bajos.
La experimentación de AutoVac en modelos animales ha sido muy satisfactoria y ha demostrado que no produce efectos tóxicos. Actualmente, se está investigando clínicamente en 27 mujeres, con cáncer avanzado. Los resultados estarán listos antes del final de este año.
Webs Relacionadas
3rd European Breast Cancer Conference
http://www.fecs.be/
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