La técnica ha sido desarrollada por el Dr. C. H. Evans, de la Facultad de Medicina de Harvard (Estados Unidos) y evaluada en ensayos clínicos de fase I en 9 pacientes estadounidenses y 3 alemanes, confirmando que se trata de un tratamiento seguro y que constituye una estrategia viable como terapia a largo plazo de la enfermedad.
Los 12 pacientes tratados presentaban artritis reumatoide avanzada. Se tomaron células de la articulación artrítica, que se cultivaron en el laboratorio y se manipularon para que produjeran un antagonista del receptor de la interleucina 1.
Al cabo de unas semanas de cultivo, las células se inyectaron en dos articulaciones. Con ello se consiguió el efecto antiinflamatorio deseado durante 6 semanas con una sola inyección, explican los investigadores, contribuyendo significativamente al alivio del dolor.
Esperan publicar estos resultados próximamente y comenzar este año los ensayos de fase II.
Webs Relacionadas
Harvard Medical School
http://www.hms.harvard.edu/
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