Es el principal resultado de un estudio publicado en "JAMA" por un equipo del Hospital Mitate (Japón). Administraron 5 mg de folato y 1.500 microgramos de vitamina B12 a 314 pacientes, y placebo a otros 314. Tras un seguimiento de dos años a más de 550 de estos pacientes, los autores escriben que se registraron 6 fracturas de cadera en pacientes que recibieron ácido fólico y vitamina B12 y 27 en el grupo placebo. La diferencia en el número total de fracturas entre ambos grupos fue estadísticamente significativa, con 8 fracturas en el primer grupo y 32 en el segundo.
Además, los que recibieron el tratamiento activo experimentaron una reducción del 38% de sus niveles de homocisteína plasmática, los cuales se elevaron en un 31% en el grupo placebo.
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