Científicos de la Universidad de Kyoto (Japón) crearon una estirpe de ratones carentes de un receptor para esta hormona y observaron que no aumentaban de peso al ser sometidos a una dieta rica en grasa. Tampoco desarrollaron resistencia a la insulina.
Además, los ratones carente del receptor del GIP y de leptina la llamada popularmente hormona de la obesidad- eran incluso más delgados que los que carecían sólo del receptor.
Nature Medicine 2002;10.1038/nm727
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Publicado el 27 de junio de 2002
Obesidad
Nueva posible diana terapéutica para la obesidad
Un trabajo publicado en la edición electrónica de "Nature Medicine" cita una hormona llamada polipéptido inhibidor gástrico (GIP) como posible diana terapéutica para la obesidad.
Científicos de la Universidad de Kyoto (Japón) crearon una estirpe de ratones carentes de un receptor para esta hormona y observaron que no aumentaban de peso al ser sometidos a una dieta rica en grasa. Tampoco desarrollaron resistencia a la insulina.
Además, los ratones carente del receptor del GIP y de leptina la llamada popularmente hormona de la obesidad- eran incluso más delgados que los que carecían sólo del receptor.
Nature Medicine 2002;10.1038/nm727